A meta-analysis of association between CTLA-4 -1722T/C polymorphisms and systemic lupus erythematosus susceptibility
نویسندگان
چکیده
Number of studies assessed the association between Cytotoxic T lymphocyte antigen-4 (CTLA-4) -1722T/C polymorphisms and systemic lupus erythematosus (SLE) was increasing. However, these studies have provided conflicting results. In this study, meta-analysis was performed to invest the correlation between CTLA-4 -1722T/C polymorphisms and SLE susceptibility. Eligible case-control studies published up to June 2015 were selected from PubMed, EMBASE, MEDLINE, CNKI and WanFang databases. Meta-analysis was performed using Stata12.0 software to analyze the data according to the inclusion and exclusion criteria. A total of 11 studies comprising 1722 SLE cases and 1829 controls were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. In addition, Begg’s test was used to measure publication bias. The meta-analysis results demonstrated that there was significant association between CTLA-4 -1722T/C polymorphisms and SLE susceptibility (TT+TC vs. CC: OR=1.80, 95% CI=1.15-2.80, P<0.05; TT vs. TC+CC: OR=1.39, 95% CI=1.04-1.85, P<0.05; TT vs. CC: OR=2.05, 95% CI=1.24-3.38; TC vs. CC, OR=1.62, 95% CI=1.06-2.49, P<0.05). When stratified by ethnicity, the association still existed for Asian population (T vs. C: OR=1.50, 95% CI=1.15-1.95, P<0.01), but no significant correlation existed for Europeans and Africans groups. In suumary, there is a significant association between CTLA-4 -1722T/C gene polymorphisms and SLE susceptibility.
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تاریخ انتشار 2016